Abstract: As the most common renal disease with diverse pathological types in children, glomerular diseases have common manifestations of isolated hematuria, isolated proteinuria, glomerulonephritis and nephrotic syndrome.Its etiologies are primary, secondary and hereditary.Clinical diagnosis of glomerular disease in children has remained confusing.It often involves clinical classification, renal pathology(including immunofluorescence) and primary etiology.Light microscopic pathological manifestations should not be applied for a primary clinical diagnosis.And a definite diagnosis should be based upon multiple levels of clinical symptoms, course of disease, etiology, primary disease, renal pathology and renal function grading.